Download Apoptosis, Senescence and Cancer (Cancer Drug Discovery and by David A. Gewirtz, Shawn E. Holt, Steven Grant PDF

By David A. Gewirtz, Shawn E. Holt, Steven Grant

This ebook presents perception into proven practices and learn into apoptosis and senescence. the quantity completely examines novel and rising concepts and study within the fields of mobilephone dying pathways, senescence development arrest, medicines and resistance, DNA harm reaction, and different issues that also carry mysteries for researchers. In overall, this quantity offers easy scientists and clinicians with a deeper and extra entire realizing of the mobile responses of malignancies that may verify the effectiveness of remedy, either within the preliminary levels of the sickness in addition to in illness recurrence.

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Int J Radiat Biol 2002; 78:643–58. 30 Part I / Apoptosis and Alternative Modes of Cell Death 265. Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74:957–67. 266. Bunz F, Hwang PM, Torrance C, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999; 104(3):263–9. 267. Merritt AJ, Allen TD, Potten CS, Hickman JA. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation.

Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev 1999; 13:3179–84. 27. Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS. Caspase-9 can be activated without proteolytic processing. J Biol Chem 1999; 274(13):8359–62. 28. Chang DW, Xing Z, Capacio VL, Peter ME, Yang X. Interdimer processing mechanism of procaspase8 activation. EMBO J 2003; 22(16):4132–42. 29. Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi Y. Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.

Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74:957–67. 266. Bunz F, Hwang PM, Torrance C, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999; 104(3):263–9. 267. Merritt AJ, Allen TD, Potten CS, Hickman JA. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene 1997; 14:2759–66.

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